August 24, 2018

Sreekanth B

Pharmacology Frequently Asked Interview Questions And Answers

Explain Which Type Of Immunoglobulin Level Will Increase When An Individual Is Exposed To A Parasite?
Serum IgE levels will increase and remain until the parasite is washed out from the body.

Explain With An Example Of Haemopoietic Growth Factor Is: Platelet Derived Growth Factor, Epidermal Growth Factor, Iron Dextran, Erythropoietin.

Explain Dose Of Acetaminophen In Children: 5-10mg/kg/day, 5-10mg/kg/dose, 10-15mg/kg/day, 10-15mg/kg/dose.

Explain Which Of The Following Hypnotic Agents Is Absorbed Slowly? Phenobarbital, Flurazepam, Triazolam, Temazepam.

Explain Flumazenil Blocks The Actions Of: Phenobarbital, Morphine, Zolpidem, Ethanol.

Explain Indirect-acting Adrenoreceptor Blocking Drug: Tolazoline, Reserpine, Carvedilol, Prazosin.

Explain The Hypnotic Drugs Induce: Increase The Duration Of Rem Sleep, Decrease The Duration Of Rem Sleep, Do Not Alter The Duration Of Rem Sleep, Increase The Duration Of Slow Wave Sleep.
Decrease the duration of REM sleep

Explain Which Of The Following Is An Antifungal, Flucytosin, Cytosine Arabinoside, 5 Fluourasil, Procarbazine.

Explain Which Of The Following Benzodiazepines Is Used Mainly For Hypnosis? Clonozepam, Lorazepam, Flurazepam, Midazolam.

Explain Oral Contraception Failure Can Occur With A/e: Ampicillin, Phenytoin, Rifampicin, Mebendazole.

Explain Do You Know How The Dose For Children Is Being Estimated Based On Preclinical Data?
There are a number of ways of estimating children's doses from preclinical (adult) data - often depends on the therapeutic index of the drug in question (the wider the therapeutic window the less accurate the child's dose needs to be). Sometimes straight weight-basis i.e. 7kg child gets 1/10 dose of 70kg adult. More accurate (so they say) is a dose based on body surface area (child's surface area is greater in proportion to its body weight than an adult is).

There are normograms to calculate surface area from weight and height of child. All of these may be wrong if clearance of drug in child is significantly different from adult e.g. different metabolism or different route of clearance.

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